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Topographic and histopathological analysis of neck nodes in patients with laryngeal carcinoma

Thesis

Last updated: 06 Feb 2023

Subjects

-

Tags

Otolaryngology

Advisors

Negm, Hesham M. , Ebrahim, Muhammad M. , Fatthi, Hesham A. , Haridi, Amal A.

Authors

El-Battawi, Ahmad Mahmoud Ahmad

Accessioned

2017-07-12 06:40:12

Available

2017-07-12 06:40:12

type

M.D. Thesis

Abstract

Objectives: Metastatic neck disease is the most important factor in the spread of head and neck squamous cell carcinoma (SCC) from primary sites, the presence of neck metastasis is known to reduce survival by 50%. Aim of the study: determining the incidence and topography of nodal micrometastasis in laryngeal carcinoma and to correlate nodal micrometastasis with site and stage of the primary tumor, nodal stage, and gross morphological and microscopic aspects of the primary tumor. Methods: 30 patients with clinically N0 nodal stage laryngeal carcinoma who underwent surgery for the treatment of the primary tumor and the possible occult cervical lymph node metastasis, the lymph node levels were labeled intra-operatively for differentiation between levels and were sent separately for histopathological examination using routine H&E staining and cytokeratin antibody staining. Results: the incidence of cervical lymph node macrometastasis was 30% (9/30) and the incidence of micrometastasis was 26.7% (8/30), the overall occult metastasis increased to 53.8% (7/13) for glottic tumors, 50% (6/12) for supraglottic tumors and 40% (2/5) for transglottic tumors. Conclusions: The routine sectioning and examination for metastasis can result in as many as 30% false negative results, so we have to combine cytokeratin staining together with the routine H&E staining. Selective neck dissection has to be done also with T3 glottic carcinoma due to high incidence of metastasis. If neck dissection is performed, en-bloc resection is very important due to the incidence of lymphatic emboli.

Issued

1 Jan 2011

DOI

http://dx.doi.org/10.21473/iknito-space/35152

Details

Type

Thesis

Created At

28 Jan 2023