The aim of this essay is to evaluate the effectiveness, efficacy and saftey of misoprostal in clinical obstetric. The PGE1, analogue “Misoprostol’ is a recent method for cervical ripining of little coast, dosn´t need any specific storage and transport conditions has a shelf half life of several years (Gouk et al., 1999). Several studies were done to reach the ideal need and route of admimistration