There are many indications for intravitreal steroid injection.Intravitreal steroid injection has a remarkable role in diabetic retinopathy.OCT and FA are used to assess diabetic macular edema before injectionand there are leakage and increased foveal thickness and by OCT and FAafter injection there is great improvement in leakage and foveal thickness.Recurrence usually happens six months later. There is a strongrelationship between visual acuity and foveal thickness. Different dosesare indicated to be suitable for each case. There is a minor role ofintravitreal steroids in proliferative diabetic reinopathy. Intravitrealsteroids can be used in combination with PRP to obtain better results. Inpatients with diabetic macular edema and cataract intravitreal steroids canbe used in combination with phacoemulsification. In CNVM intravitrealsteroids are used to decrease the neovascular membrane and to improvethe visual acuity according to the dose. Better results obtained bycombination of intravitreal steroids and PDT. All types of CME havebenefit from intravitral steroids of 25 mg. In recent non ischemic andischemic CRVO, reversing of CME and improvement of visual acuityoccurs. Intravitreal steroids can be used as an adjunctive therapy forneovascular glaucoma. Uvietic CME and refractory uvietis improved byintravitreal steroids.