There has been great interest in the last few years in the pathogenesis of diabetic vascular complications. Diabetic subjects exhibit a high prevalence of accelerated atherosclerois, the exact etiology of the pathogenesis of this is uncertain but numerous observations support the theory that chronic low-grade inflammation is involved in the progression of atherosclerosis. A feature of inflammatory activity is the increase in circulating plasma concentrations of acute-phase proteins produced by the liver, one of the most sensitive acute-phase proteins is C-reactive protein (CRP) and during an acute inflammation the concentration can increase several hundredfold. We studied 60 cases and 10 control subjects. They were subjected to clinical examination and laboratory work-up in the form of blood sugar, glycosylated hemoglobin (HbA1c), C-reactive protein (CRP), fibrinogen and plasminogen activator inhibitor-1 (PAI-1) in addition to routine laboratory work-up. Statistical analysis was done to demonstrate any relation between diabetic vascular (macro- & micro-) complications and those clinical and laboratory parameters.CRP was higher in patients with vascular complications when compared to controls. The incidence of CRP positive patients was only statistically significant when patients with macro-vascular complications where compared to controls. HbA1c and PAI-1 were statistically significantly higher when patients were compared to normal controls. Fibrinogen was found to be high in all patients and controls with no statistical significance. A statistically significant correlation between body mass index (BMI) and PAI-1 was found on comparing all cases and controls.