Objective: To assess the level of soluble tumor necrosis factor receptor p75 in the serum of children having SLE and its correlation with the various clinical parameters and disease activity. Methodology: Levels of soluble p75R were determined by a solid phase Enzyme Amplified Sensitivity Immunoassay (EASIA) in forty pediatric patients having SLE compared to 10 healthy matched controls. Results: Serum levels of s.p75 R was significantly higher in the cases than in the controls. It was significantly higher in ANA +ve patients than in ANA –ve patients than in healthy controls. It was also higher in anti DNA +ve patients than in anti DNA –ve patients than in controls. It also correlated with disease activity being higher in active disease than in inactive disease than in controls. It correlated positively with ESR, BUN and creatinine. In all the previous results the p value was <0.05 i.e statistically significant. Conclusion: S.p75 R is an important tool in the diagnosis of SLE. It is also a valuable marker for monitoring disease activity.