This work has been performed to examine the effect of two drugs with antioxidant properties; N-acetylcysteine and allopurinol, singly or in combination on cyclosporine induced nephrotoxicity in albino rats. The rats were randomized into 8 groups, 10 rats each, and were given the following drugs for 21 days: cyclosporine at a dose level of 15 mg / kg body weight / day by subcutaneous injection in cremophor vehicle, cyclosporine plus N-acetylcysteine (140 mg / kg body weight / day orally), cyclosporine plus allopurinol (10 mg / kg body weight / day orally), cyclosporine plus N-acetylcysteine and allopurinol, N-acetylcysteine alone, allopurinol alone, and cyclosporine vehicle alone (cremophore EL). The rats were sacrificed and evaluated for the kidney function (serum urea, creatinine, and urea / creatinine ratio), kidney histo-pathological changes, and serum and kidney lipid peroxide (malondialdehyde). The obtained results demonstrated that N-acetylcysteine and allopurinol afforded nearly similar partial protection, both functional and structural, against cyclosporine- induced nephrotoxicity, and reduced oxidative stress induced by cyclosporine in albino rats. It was also demonstrated that the protective effect was greater with both N-acetylcysteine and allopurinol than with either drug alone.