A novel of artial natriuretic is hormone secreted from the right atrium which has a natriuretic effect and the present study have shown a significant elevation of the level of ANP in cases of ischaemic heart with heart failure, hypertension and ischaemic only patients respectively in comparison to control group, also there are a significant elevation in acute myocardial infarction, unstable angina, old myocardial infraction and stable angina in comparison with group respectively.