Objectives : Assessment of p53 protein immunostaining in hepatocellular carcinoma and analyzing it’s association with the expression of Factor VIII-Related antigen to investigate the role of p53 in the regulation of angiogenesis.Material & Methods : Twenty cases of hepatocellular carcinoma were collected and assessed for tumour pattern, grade, microvessel density (MVD) and p53 expression.Results: Among the studied sample, 60% of cases were of trabecular type, 10% acinar type, 10% solid type, 15% clear cell type and 5% scirrhous type. Grade II was the most frequent representing 45% of cases followed by grade I, 35% and Grade III, 20%. p53 was positively expressed in 35% of cases and was correlated significantly with high grade tumours. Eleven cases (55%) showed low MVD while 9 cases (45%) showed high MVD with a direct relation between MVD and tumour grade in most of the cases. p53 immunoreactivity was significantly more intense in tumours with high MVD (57.1%) than in those with low MVD (42.9%).Conclusions & Recommendations : p53 mutation is common in hepatocellular carcinoma with a significant correlation between p53 positivity and tumour grade. The present work demonstrated a significant association between p53 expression and MVD suggesting a putative influence of this tumour suppressor gene on the development of argiogenic pattern and confirming the preclinical data that angiogenesis may be regulated through p53 gene function . A more detailed analysis of angiogenic factors expression in human tumour samples will provide useful information about the genetic control of argiogenic phnenomenon in cancer