Forty one GH deficient children (28 of them males) were evaluated, mean age of 12.1 yr ± 2.6. They were divided into two major groups, group (1) 10 were non treated, second major were received rhGH therapy for different durations (22 ± 16.2 month), with average weekly dose 12-20 IU/m2 /wk were subdivided into group 2,3and 4 according to duration of therapy. 21 healthy children as control. M-mode echocardiography was done showed increase in IVSd and LVEDD dimensions in group 1, in comparison to control and during early treatment with lesser increase during longer durations. MPI revealed transiently correction of diastolic dysfunction during second year of therapy.