Gallstones is a common disease with relatively dangerous, sometimes life threatening complications. 40 cases of gallstones were studied preoperatively comparing the results of conventional ultrasonography and endosonography as regard wall thickness, calcification, mud stones and acoustic shadows. Ultrasonography is safe, fast relatively inexpensive. It is the study of choice for patients with suspected biliary colic. Positive findings include stones, wall thickness, positive Murphy's sign.Endosonography, although proved to be relatively more accurate in detecting wall thickness and microlithiasis (P value 0.000), but is invasive and uncomfortable to patients. Gallbladder polyps are a common incidental finding on Transabdominal Ultrasonography, they have been reported to occur in 5% of the population. Gallbladder carcinoma is relatively uncommon but carries a very poor prognosis even if it is identified early. EUS has recently been shown to be efficacious for detection and preoperative assessment of the depth of invasion of gallbladder carcinoma. This study assessed the value of EUS in detection of gallbladder carcinoma and correlation between preoperative EUS images and postoperative histopathological results of the lesion