Background and objectives: The migration of leukocytes into the tissues is the central event in the inflammatory response. Leukocyte emigration is responsible for the successful host response to tissue injury and infection, but is also potentially harmful and contributes to the pathology of many diseases and inflammatory disorders. Cellular adhesion molecules (CAMs) are cell surface glycoproteins involved in cell-cell and cell-matrix interactions. They are highly involved in the pathogenesis of hepatocellular necrosis initiated by cytotoxic T lymphocytes. Methodology: study of the soluble forms of CAMs; the most important of which ICAM-1, VCAM-1 and E-selectins representing the three main molecular families of adhesion molecules; in the sera of thirty Egyptian patients with chronic HCV infection. Whether associated with schistosomal periportal fibrosis or not. Patients had done liver needle biopsy, abdominal Ultrasonography, liver markers for HCV as well as estimation of levels of soluble CAMs. 4 patients are said to have schistosomal periportal fibrosis. 10 sex and age matched controls are studied also. Results: levels of CAMs were significantly elevated as compared to controls. We did not find correlation between CAMs and degrees of liver inflammation and fibrosis nor between HCV chronic liver disease alone and mixed cases with schistosomiasis. Conclusion: CAMs may be an easy and noninvasive follow up markers of liver inflammation and fibrosis in chronic HCV patients under treatment.