Lead is one of the most wide spread environmental toxins because of its presence in Soil, water and air. The present work demonstrated that lead produced variable histological alterations in the testes of rats. These changes appeared as low degenerated spermatogenic epithelium with wide aspermatic lumen, vacuolation and radial degeneration. These changes might be due to oxidative stress and generation of reactive oxygen radicals. The administration of vitamin E was found to reduce the observed harmful effects of lead on the testes thus suggesting that this antioxidant might have a protective role against lead toxicity.