Thyroid hormones are necessary for normal skeletal growth, maturation and bone turn over. Hyperthyroidism is accompanied by osteoporosis or osteopenia with increased rates of bone formation and bone resorption with predominance of resorption and higher incidence of fracture rates.20 males and 20 premenaupasal females with thyrotoxicosis and 10 normal control males and 10 normal control females of coparable age were studied for routine labs, thyroid function, serum Ca, serum phosphorus, total ALP, BALP, urinary Ca and creatinin, thyroid ultrasound and scan and DXA of the forearm and the results were statistically analyzed. BMD was significantly lower in thyrotoxic in comparison to euthyroid subjects (P<0.001) whereas ALP, BALP and urinary Ca were significantly higher in thyrotoxic in comparison to euthyroid subjects (P<0.001).