Pre-eclampsia is a disease with world wide significance to mothers and infants. Its greatest impact is in developing countries, where it accounts for 20-80% of maternal mortality. Endothelial microparticles play a role in the endothelial dysfunction and their measuments may be useful as a diagnostic tool for pre-eclampsia in pregnant women. Material & Methods: endothelial microparticles are measured in 43 pregnant patients with pre-eclampsia, pregnant more than 20 week gestation, not chronically hypertensive, not having chronic renal or liver disease not diabetic not having history of recurrent pregnancy loss nor smokers and 28 normotensive pregnant women as matched control group. Results EMP was significantly higher in pre-eclamptic patients versus normal pregnant (EMP counts range: [6054-26622 count/ l] in mild pre-eclampsia versus [9424-43586 count/ l] in sever pre-eclampsia versus [1260-9777 count / l] in control group, P < 0.001).PMP count was not significantly different in pre-eclamptic patient from control group (PMP count range: [1884-20984 count/ l] in mild pre-eclampsia versus [612-15500 count/l] in severe pre-eclampsia versus [1279-21272 count/l] in control group, P = 0.957). EMP was significantly correlated to uterine RI and PI. RI (r = 0.374, P = 0.001) and PI (r = 0.345, P = 0.003). EMP was also significantly correlated to umbilical RI not PI. RI (r = 0.424, P < 0.001), and PI (r = 0.182, P = 0.128).EMP was significantly correlated to poor maternal outcome. (higher maternal serum AST, r = 0.291, P = 0.014) higher maternal bilirubin, r = 0.474, p = 0.000, lower platelet count, r = - 0.374, P = 0.001). EMP was significantly correlated to poor perinatal outcome (P = 0.004). Conclusion: EMP was significantly higher in pre-eclamptic pregnants with significant correlation to increased uterine RI, PI and umbilical RI not PI and bad maternal and neonatal outcome.