Study Design: This study retrospectively examines outcomes oftransforaminal lumbar interbody fusion (TLIF) technique in themanagement of degenerative diseases of lumbar spine.Objectives of the study: To assess the clinical and radiographic outcomeof TLIF, to describe the technique and indications in the treatment ofdegenerative disease of the lumbar spine, and to demonstrate the safety,surgical efficacy, and advantages of the transforaminal approach forlumbar interbody fusion.Methods: We retrospectively reviewed thirty three patients treated withTLIF for degenerative diseases of the lumbar spine who were followed upfor a minimum of 1.5 years (mean: 18 months; range: 12–24 months).Twelve patients had degenerative disc disease, 15 had isthmic ordegenerative spondylolisthesis, 2 had canal stensios with instability and 4had failed previous back surgery.Results: Low back pain completely resolved in 22 patients, moderaterelief from pain was achieved in 9 patients, and the pain was unchangedin 2 patients. Thirty patients (90%) had solid radiographic fusions at latestfollow-up, and confirmed pseudoarthrosis rate of 1 of 33 (3%).Complications included intraoperative dural tear in two patients andpostoperative wound infection in two. Two patients suffered a transientextensor paresis. One case showed cage loosening and mild retropulsion.Conclusions: Transforaminal lumbar interbody fusion is a safe andeffective method for achieving circumferential spinal fusion via a singlestageprocedure. This procedure is particularly useful in restoring discspace height and lumbar lordosis. Interbody cages in spondylolisthesis areuseful to increase neuroforaminal height, to facilitate reduction, and toimprove the chances of achieving a successful 360° fusion.