Interaoperative use of elective hypotension in cerebral aneurysm surgerydecreases the incidence of hemorrhage, provides a dry field and allows safe application ofocclusive clips. Sevoflurane and propofol are widely used in neuroanesthesia, as bothdrugs have favorable effects on cerebral circulation and metabolism. Monitoring ofcerebral oxygenation during clipping of cerebral aneurysms under induced hypotension,using jugular bulb oxygen saturation allows the detection of the minimal mean bloodpressure which provides a balance between the risk of aneurysm rupture before clippingand the incidence of cerebral hypoperfusion or ischemia. Also monitoring of cerebralmetabolism by measuring jugular bulb lactate and pyruvate as a proper indices ofanaerobic metabolism during surgery for aneurysm clipping with different anestheticplanes; sevoflurane versus propofol allows the detection and prevention of cerebralischemia as well as ensuring cerebral protection during this critical time.Anesthesia with induced hypotension in neurosurgery represents a challenge forthe anesthesiologists. In this study we compared 2 anesthetic techniques using shortacting drugs with minimal effects on systemic or cerebral hemodynamics. Bothtechniques, propofol and sevoflurane, provided favorable conditions for surgery, thoughstatistically more decrease in the cerebral oxygenation and tissue perfusion was foundedin the propofol group(reflected by ↓Sjvo2 and ↑AJDO2 & COE as well as↑jugular bulblactate and pyruvate) compared to sevoflurane group. Further studies are needed on awider scale in various neurosurgical procedures for verification and evaluation of theeffects of propofol on cerebral oxygenation and metabolism.