Objective: This work aimed to compare the safety and efficacy of unilateral total and contra lateral subtotal thyroidectomy versus bilateral subtotal thyroidectomy for the treatment of hyperthyroidism.Patients & Methods:30 Patients who were suffering hyperthyroidism i.e., Grave's disease or Toxic nodular goiter, divided to two groups:•15 Patients were managed by unilateral total and contra lateral subtotal lobectomy.•15 Patients were managed by bilateral subtotal thyroidectomy.Both Groups were assessed pre and post operative to compare the incidence of complications regarding RLNI, parathyroid gland injury and postoperative need for T4 replacement.Results: No significant difference in the incidence of complication between both groups i.e. Unilateral total and contra lateral subtotal lobectomy versus bilateral subtotal lobectomy.Conclusion: Unilateral total and contra lateral subtotal thyroidectomy can be used effectively and with the same incidence of complication as subtotal thyroidectomy with logical lower incidence of recurrence.