This work is a retrospective study to compare between the efficacy and tolerability of taxanes versus vinorelbine & 5FU arms.These patient were assessed clinically radiologically. So we conclude that taxanes therapy is feasible, has excellent activity and has nonsignificant statistically difference in mean OAS, mean PFS, mean DFP and toxicity in comparison to navlbine & 5fu except for fluid retention And neurosensory changes but this will need more patients’ number to confirm such results