Childhood wheeze is common. It usually begins in early life, and may then persist into later life. Asthma is preceded by a stage of recurrent episodes of wheezing during the first years of life and proper treatment during symptomatic episodes may delay progression to persistent asthma. Th2 type cytokines,IL-4 is a as key regulator factor in asthma. INF-γ antagonizes IL-4-dependent IgE production. IL-4/ IFN-γ ratio was greater in children with asthma compared with control children The aim of this study is to determine the level of IL-4 and INF-gamma in early onset wheezy children to detect those who may develop asthma for early prevention and better prognosis.