37027

Evaluation of diffusion weighted echo planar MR imaging in the characterization of focal hepatic lesions

Thesis

Last updated: 06 Feb 2023

Subjects

-

Tags

Radiodiagnosis

Advisors

El-Toukhi, Muhammad M. , Hamed, Muhammad M. , El-Shantali, Khaled M.

Authors

Hasanain, Muhammad Ahmad

Accessioned

2017-03-30 06:21:13

Available

2017-03-30 06:21:13

type

M.D. Thesis

Abstract

Diffusion weighted echoplanar imaging was developed as one of the recent imaging techniques aiming at improving the specificity for characterization of focal hepatic lesions. The development of echo planar imaging greatly influences the success of application of diffusion technique in abdominal studies as it provides very high speed imaging reducing the problem of motion artifact during image acquisition. The effect of diffusion depends on the fact that produces a reduction of the signal intensity in each pixel. Such performed studies have concluded that malignant solid lesions had smaller ADC values than benign lesions and that in benign lesions the ADC values of haemangiomas were smaller than those of cysts. More over other performed studies suggest that diffusion weighted imaging was useful in differentiating abscesses form cystic or necrotic tumors as they found that the ADCs of hepatic abscesses were significantly smaller than necrotic or cystic tumors. Forty-seven cases were included in our study with all have underwent conventional non contrast MR imaging preliminary to the diffusion scan. Calculation of the apparent diffusion coefficient was performed by measurements of the signal intensities in the region of interest using two gradient factors low and high ( b 30 and 1,200 sec/ mm2 respectively). Our study have concluded that benign lesions have generally a higher ADC values than malignant ones and that among the studied benign lesions cysts elicit the highest ADC values followed by haemangiomas and then abscesses while for malignant lesions primary hepatic carcinomas had lower ADC values compared to metastatic lesions. From the calculated ADC values of all studied cases a threshold value of 1.5 was suggested to differentiate between benign and malignant lesions and definite benign lesions can be diagnosed with lesions having an ADC value of 2.2 or above while definite malignant lesions have an ADC value of 1.0 or less. We had also found that most of benign lesions had lost the signal brightness after rising the b value (1,200) while most of malignant lesions retain their signal intensity. From the result obtained in our study we had suggested a protocol for the imaging diagnosis of focal hepatic lesions and we had concluded that diffusion MR scan is a useful complementary technique to conventional MRI which could replace the post contrast MR study or sometimes enhanced CT scan in achieving a definitive radiological diagnosis.

Issued

1 Jan 2005

Details

Type

Thesis

Created At

28 Jan 2023