Coronary heart disease represent a major cause of death worldwide. Adiponectin is an important adipocytokine that shows a number of antiatherogenic and insulin sensitizing effects. Measurement of Adiponectin may be a helpful tool for assessment of the risk of CAD and may represent a novel diagnostic tool for risk stratification of patients with myocardial ischaemia. Adiponectin is an independent predictor of coronary artery disease.