The results of surgical treatment for esophageal squamous cell cancer have improved over recent decades, but the long-term prognosis for patients with tumors of stage II or higher are still unsatisfactory. A review of literature was conducted to determine the effect of multi-modality therapy for squamous cell carcinoma of the esophagus examining the effect of neo-adjuvant or adjuvant treatment on the long-term survival of patientsResults came up with no improvement in the survival with adjuvant radiotherapy or chemotherapy also following neo-adjuvant radiotherapy or chemotherapy or both, respectability was not improved, the postoperative mortality rate appears to be higher and survival was not prolonged