Several methods are available for cervical priming before induction of abortion as well induction of labor. In this study, one of these methods, the PGE, analogue “Misoprostol” is being discussed as a recent method for cervical priming, being very close to the criteria of an ideal cervical priming agent. Several studies were done on this drug for the past few years. This study is a trial to reach the ideal dose and route of administration of misoprostol through presenting the different studies that have been performed on the application of misoprostol.