Choleystectomy is a common surgical procedure which is nearly done on daily basis in any institute patients who underwent cholecystectomy for symptomatic gallstone may still have dyspeptic symptoms. Our study evaluates the effect of cholecystectomy on duodenogastric reflux, Gastric mucosa and the serum gastrin level. We concluded that duodenogastric reflux is more frequent in gallstone patients than in healthy individuals and that its incidence and grade increase after cholecystectomy. Douderogastric reflux causes consequently a degree of chronic gastitis which may play a role in persistence of symptoms after cholecystectomy.