This study was conducted retrospectively on the charts of all patients (196 cases) of JIA followed in Pediatric Rheumatology Clinic in Abu El-Reesh Hospital, Cairo University. Methods: Ninety four Patients of them are males and (102) patients of them are females. Their ages ranged from 3 to 25 years, with a mean age of (11.93± 4.423) years.The study aims to evaluate the clinical presentation, course and associated risk factors of cases of JIA in Egyptian children.Results: There was a slight predominance of the disease in females; male- to-female ratio was 1:1.09. And there was a positive family history in 11 cases, (5.6%) of JIA patients. Our study group included patients from different governorates all over Egypt with more or less similar frequency both in urban and in rural areas. The main clinical manifestations in our study were morning stiffness and fever. The highest frequency was for oligoarticular type, 41.3% 0f cases (n=81). Slit lamp examination showed positive findings in 5.6% of patients (n= 11). Laboratory investigations showed positive ANA in 37 cases, (18.9%), and 83 cases (42.3%) were diagnosed to have mild to moderate anemia. Death rate was (0.5%) due to disease complications. Conclusions: Long duration and chronicity of the disease leaded to the occurrence of complications. Early detection and follow up may reduce the incidence of complications and improve the outcome and quality of life of JIA patients.