Ginger can prevent the increase in cholesterol level following intake of cholesterol rich diet .Ginger also is known to possess antioxidant properties. Researches involved the plants traditionally used to support the liver functions and treat diseases of the liver. Ginger appears to improve gastric motility secondary to its anti-spasmodic effects. In this study ginger was given in three doses (100,200 & 400 mg /kg) to hypercholesterolaemic rats ,also it was given in doses(100,200 & 400 mg /kg) to rats at 12 hours intervals for 48 hours prior to single overdose of paracetamol (640 mg /kg ) to study its hypocholesterolaemic and hepatoprotective effects on rats in vivo. Its antispasmodic effect was studied on ACh-induced contractions in rat jejunum in vitro.