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Retinal findings in systemic sclerosis patient : Its relation with nail-fold capillaroscopic patterns, and disease severity parameters

Thesis

Last updated: 06 Feb 2023

Subjects

-

Tags

Rheumatology & Rehabilitation

Advisors

Allam, Nashwa T., Abdel-Hamid, Alaa M., Nawaytou, Zainab A.

Authors

Abdel-Qader, Huda Mahmoud

Accessioned

2017-04-26 12:05:36

Available

2017-04-26 12:05:36

type

M.D. Thesis

Abstract

Systemic sclerosis (Ssc) is a multisystem connective tissue disease characterized by cutaneous lesions of the small arteries, leading to an obliterative vasculopathy. Although patients with Ssc are known to have a variety of vascular abnormalities, retinal vascular damage is not well understood. Retinal vascular changes may reflect cerebral and sometimes general vascular changes. Architectural abnormalities of the microvasculature which are also characteristic of Ssc are easily visualized by nail fold capillaroscopy.The objective of this study was to determine the prevalence of retinal disease in systemic sclerosis (Ssc) and to characterize the findings of retinopathy. Additionally to analyse the association of retinal disease with other clinical and laboratory findings, particularly the findings of nailfold capillaries in patients with Ssc.The results showed that the retinal findings of the patients with Ssc consisted of hard exudates, vascular tortuosity, micro-haemorrhage and macular degeneration. The patients with Ssc was 34% (10/30), compared with 8% (3/30) among the controls. The disease duration of the patients in group A were significantly higher than those in group B. however, there was no significant difference in the nailfold capillary damage between group A and B. In conclusion, the retinal abnormalities are often seen in patients with Ssc and they may reflect the vascular changes characteristic of Ssc. However, retinal changes may differ in quality from the changes of nailfold capillaries.

Issued

1 Jan 2008

DOI

http://dx.doi.org/10.21473/iknito-space/32155

Details

Type

Thesis

Created At

28 Jan 2023