In the present study, five selected antigens (Schistosoma mansoniExecretory – secretory (E /S) antigen S. mansoni cercarial Ag, F.Gigantica (E/S) Ag, Toxocara canis crude Ag and Cysticercus CellulosaeCrude Ag) were Prepared . They were Used in Vaccination of separateGrodps of mice. The level of protection Versus S. mansoni infection afterVaccination Was estimated Via 3 Parameters including : Reduction in theProduced Worms; Degree of histo -pathological Changes recorded in liver& Spleen; Alteration in the level of immunoglobulins in Sera ofVaccinated mice before and after challenge with Special references toDetermination t the level of Cross -reaction between each type of theProduced antibodies and that produced against S. mansoni.