Background: Syndrome X (the metabolic syndrome) is a cluster of physiologic and metabolic abnormalities including hyperglycemia, hyperinsulinemia, hypertension and hyperlipidemia.Objectives: To investigate the effect of Simvastatin and Fluvastatin on insulin resistance, lipid profile and e-NOS gene expression in fructose enriched diet (FED) rat model.Methods: 40 male Sprague-Dawley rats were divided into 4 groups, each one contains 10 rats.Group I (control group), Group II (fructose fed), Group III (Simvastatin treated fructose fed), and Group IV (Fluvastatin treated fructose fed).