Surgical Procedures initiate inflammatory responses, which areessential for maintaining the homeostatic state during the post-operativecourse.The balance between immune stimulatory and immune suppressivemechanisms is affected by pre-operative health status, extent and durationof surgery, drug treatment, anxiety, and pain.General anesthesia may impair the inflammatory responses, eitherdirectly by disturbing functions of immune cells or indirectly bymodulation of the stress response.Cytokines are protein mediators that exert their effect by binding tocell surface proteins to regulate immune response.Pro-inflammatory and anti-inflammatory cytokines are involved in theinitiation, control, and termination of the cellular events that occur at each stage of wound healing, primarily by their chemoattractant and mitogenproperties and furthermore by their ability to stimulate cellularproliferation.It was obvious that the Propofol has the least effect on inflammatoryresponse to surgical operations than the Sevoflurane whether on major or minor surgical operations.