Systemic lupus erythematosus (SLE) is a potentially severe frequently disabling autoimmune disease with multiorgan involvement, liver is less commonly involved. This study aimed to detect the frequency and nature of liver involvement in SLE patients and to correlate these with other organ involvement and management. We reviewed (200) SLE patients who had admitted at Rheumatology and Rehabilitation Department, Faculty of Medicine, Cairo university. All patients were subjected to laboratory investigations include (AST, ALT, HCV) and abdominal ultrasound, Doppler and liver biopsy when needed. Regarding the different systems involvement liver involvement was found in 42 SLE patients (21%) which is the less commonly affected organ. We classified the 42 patients into 7 major groups: autoimmune hepatitis in 6 patients (26%), cholangitis in 1 patient (4.3%), portal venous thrombosis in 2 patients (8.6%), cirrhosis in 1 patient (4.3%), liver congestion in 1 patient (4.3%), fatty changes in 13 patients (56.6%), viral hepatitis in the form of HCV in 6 patients (26%). We classified the 200 SLE patients into group A (6 patients with AIH), group B (194 patients without AIH), group C (13 patients with fatty changes), group D (187 patients without fatty changes), group E (6 patients with HCV) and group F (194 patients without HCV). The mean age of disease onset and the mean SLICC were significantly higher in group A than group B. Liver involvement in SLE is the least organ affected. No detected difference considering liver involvement among different cities all over Egypt. The younger the age group of lupus patients with AIH, the more organ damage.