Hematological malignancies are linked to varieties of musculoskeletal manifestations. 50 cases (25 leukemia and 25 lymphoma) were collected from Cairo University Hospital. Cases were subjected to full history taking, thorough clinical examination, laboratory and radiological investigations. Results revealed 17 cases had musculoskeletal symptoms in leukemic cases, 2 had rheumatoid like manifestations, 3 had polyarthritis, 3 had OA. Knees, 3 had fasciitis, 3 had L.B.P. and 4 had fibromyalgia. In lymphoma cases 18 cases manifested musculoskeletal symptoms, 1 had rheumatoid like manifestations, 4 had polyarthritis, 7 had OA. Knees, 1 had fasciitis, 2 had L.B.P. and 3 had fibromyalgia.