Peripheral neuropathic disorders can be divided into myelinopathies and axonopathies. These conditions can be hereditary or acquired. Each of these disorders has distinct clinical features that enable neurologist to recognize the various patterns of presentation, and then further laboratory studies including electrodiagnostic testing nerve biopsy, and blood and cerebrospinal fluid examination can be performed to confirm the clinical impression. Therapy is available in some to correct the underlying disease state or at least to improve symptoms and the patient’s quality of live physically and emotionally.