Tyrosine-Kinases constitute a family of proteins which include both receptors and non-receptors. EGF receptor important transmembrane receptor member of the family of tyrosine kinases, that translates signals from both outside and inside the cell and plays key role in numerous processes that affect tumor development, growth, progression, differentiation, inhibition of apoptosis and metastasis( Vosaughhosseini et al., 2012). EGF receptor signaling is induced by ligand binding to their extracellular domain causing conformational changes to the receptor, which promote formation of homo- or heterodimers between receptor family members. Dimerization is in turn activates the intracellular tyrosine kinase and leads to autophosphorylation of one or more of the tyrosine residues in the intracellular carboxy-terminus. These phosphorylated residues act as docking sites for several adaptors and docking molecules which in turn activate downstream pathways. EGFreceptor and its downstream signaling pathways are involved in multipleaspects of cancer cell biology including proliferation, inhibition ofapoptosis, metastasis and angiogenesis ( Myers et al., 2002).