Objective: This study aimed to assess the accuracy of radiomorphometric indices measured on digital panoramic and CBCT images by comparing them to gold standard measurements on dry mandibles and to assess the effectiveness of radiomorphometric indices measured on digital panoramic and CBCT images as osteoporosis predictors in healthy and osteoporotic women. Methods: Ten mandibles were scanned by Digital panorama and CBCT. Twenty selected female volunteers were scanned by Digital panoramic, DEXA and CBCT scans. According to the DEXA results, they were categorized into either normal or osteopenic/osteoporotic group. Certain indices were measured on the digital panoramic image and CBCT images of both the mandibles and the volunteers.Result: The in-vitro study demonstrated that there was a statistically significant positive direct correlation between real, panoramic and CBCT measurements. The clinical study demonstrated that there was no significant correlation between the DEXA results with either panoramic or CBCT indices. Conclusion: Panoramic measurements are accurate and effective. All CBCT measurements specially the vertical measurements performed on cross sectional cuts were highly representative of the real measurements. Within the limitation of the current study regarding the limited sample size in the clinical sector, the bone of the mandible does not appear to reflect the characteristics of the skeleton as a whole.