Osteoporosis and periodontal disease share several common etiological risk factors, and research supports the idea that osteoporosis independently influences alveolar bone height loss. This study was undertaken in an attempt to assess the effect of Omega-3 fatty acids, as an adjunctive therapy from nutritional origin, in treatment of osteoporosis using DEXA, and in treatment of periodontitis using clinical and direct digital radiographic densitometric analysis. This study also aimed to compare the effect of Omega-3 fatty acids used medically with Rutin+VitaminC to Rutin+VitaminC used alone in the treatment of both diseases (osteoporosis and chronic periodontitis).Twenty four postmenopausal females treated from osteopenia or osteoporosis and chronic periodontitis were included in the current work. Patients were divided into two groups: 1) Omega-3 Group (O3): 13 subjects were given 1gm omega-3 FAs daily, plus Rutin-C. 2) Control Group (C): 11 subjects were given Rutin-C (50 mg Rutin + 100 mg vitamin-C) once daily. These medications were given for 9 months. Scaling and root planning was done to all patients before medical treatment. Spinal & femoral neck BMD was measured by DEXA after 6 months and 9 months, as well as alveolar bone density bilaterally in patients of both groups. Periodontal Indices taken at 6 and 9 months were: plaque Index, Papillary Bleeding Index, Pocket depth and Clinical Attachment Loss (CAL).The results of the spinal & femoral neck BMD were non-significant for either group. Omega-3 group significantly caused an increase in density measurement of alveolar bone after 6 months but this increase was not significant after 9 months. Chronic Periodontitis indices improved in both groups after 6 and 9 months, some were significant favoring omega-3 group (plaque index after 9 months), some were significant favoring control group (Papillary bleeding Index after 6 & 9 months, and pocket depth after 9 months), meanwhile, others were non-significant for the two groups (CAL after 6 & 9 months, plaque index and pocket depth after 6 months).From the presented results, the following conclusions could be conducted:-A combination of Omega-3 and Rutin-c or Rutin-c used individually is considered a beneficial nutritional supplementation that could enhance and improve alveolar bone density in osteoporotic/osteopenic female patients.A combination of Omega-3 and Rutin-c or Rutin-c used individually is considered a beneficial nutritional supplementation that might improve the PI in chronic periodontitis cases, yet their impact on remaining gingival and periodontal conditions was not established in the current work and is still questionable.