Objective: The purpose of this study was to assess thecapability of diffusion weighted imaging and magnetic resonancespectroscopy in probing the proclivity of malignancy in diseases.Subjects and Methods: Twenty-one patients with lesions in themaxillofacial area were enrolled in this study through consecutivesampling. Diffusion weighted imaging and magnetic resonancespectroscopy were performed for all candidates, where apparent diffusioncoefficient values, choline and lactate metabolites were assessed.Results: Lactate had the highest diagnostic capability, whereas cholinewas the lowest with no diagnostic significance. According to likelihoodinterpretation, lactate and ADC map3 showed the best performance.Conclusion: The integration of diffusion weighted imaging and magneticresonance spectroscopy had a great impact in the differential process ofbenign from malignant entities.