Objective: The aim of this study is to assess the effect of association of two different laser parameters with porous titanium granules on bone repair in surgically induced osseous defects in rabbit tibia. Materials and methods: Thirty adult male rabbits were used in this study. Two holes were created in each tibia. In the left tibia the upper hole used as control while the lower one was packed with porous titanium granules (PTG). Diode (GaAlAs) 980nm with power 0.5 w and 1 w was applied to the upper and lower holes in the right tibia respectively. The holes were then packed with PTG. The rabbits were divided in three groups I, II & III (10 rabbits each) according to the date of sacrifice 2, 4 and 6 weeks respectively. The specimens were then subjected to bone density, scanning electron microscope, histological and morphometrical analyses. Results: Marked deposition of new bone was seen in PTG grafted defects compared to control ones. Early new bone formation as well as advanced pattern of maturation was evident after association of Laser irradiation with PTG. Laser operated at power 1 w showed advanced course of bone repair as compared to power 0.5 w. Conclusions: In the present study the PTG showed a promising osteoconductive property. Laser treatment when combined with PTG can enhance bone repair than using PTG alone.