Purpose: This study was designed to evaluate the effect of low intensity pulsed ultrasound on healing of mandibular fractures radiographically using cone beam computed tomography (CBCT). Materials and Methods: Sixteen male patients suffering from mandibular fractures were randomly divided into two equal groups; one group acted as a control group and the other as low intensity pulsed ultrasound (LIPU) treated group, maxillary mandibular fixation was performed for the patients of both groups. In the LIPU group the second postoperative day LIPU application was started with intensity of 40 mW/cm2, 1 MHz operation frequency, 20 minutes/day the sessions were repeated for 15 days, 5 sessions per week for a period of three weeks. Healing of bone was evaluated by densitometric analysis using cone beam computed tomography (CBCT) at 30 days and 60 days postoperatively. Results: there was no statistically significant difference between the two groups concerning mean bone density at 30 days or 60 days postoperatively, no statistically significant difference within each group between the 30 days and 60 days in the mean value of bone density, and the mean percentage change in bone density within the same group was higher in group B (control group) than group A (test group). Conclusion: Radiographic assessment of bone density during healing showed that LIPU with the parameters used in the current study had no significant effect on mineralization of fracture callus.