Purpose: The aim of this study was to compare between dexmedetomidine and midazolam for intravenous conscious sedation in minor oral surgery. Patients and Methods: Twenty healthy patients scheduled to undergo a minor oral surgery were included in this study. Either dexmedetomidine (group I) (1 μg. kg -1) or midazolam (group II) (0.1 mg • kg-1) was administered intravenously until the Ramsay Sedation Score (RSS) reached four or the maximum dose limit was achieved. Recovery time was established when RSS reached 2. Numerical Rating Scale was used for assessment of pain of local anesthesia injection, postoperative pain and patient satisfaction. Analgesic consumption for 24 hours postoperatively was recorded. Amnesia was evaluated by the patients’ ability to recall the pictures shown after sedation onset. Cardiorespiratory data were collected for evaluating drug safety. Results: Sedation was achieved by median doses of 69.3 μg or 1 μg/kg dexmedetomidine and 6.3mg or 0.1 mg/kg midazolam. A significantly higher number of patients showed pain reactions in midazolam group. Very weak amnesia was observed in dexmedetomidine group. The heart rate and blood pressure measurements were significantly lower in dexmedetomidine group. There was no significant difference in the respiratory findings. Conclusion: Dexmedetomidine is a reliable alternative to midazolam for intravenous sedation.