Aim: To compare the clinical and 3D volumetric socket bone preservation using Hemi Hydrated Calcium Sulfate (CaSO4.1/2H2O) versus Plasma Rich Fibrin (PRF) assessed by 3D cone beam computed tomography.Patients and methods: 26 patients were treatment planned for extraction of mandibular anterior teeth, leaving 72 sockets for the study. Sockets were divided into 3 groups, each group consisting of 24 sockets. Sockets were grafted as follows: Group (A) sockets were grafted with calcium sulfate, Group (B) sockets were grafted with PRF and Group (C) sockets without graft as a control group. Cone beam computed tomography (CBCT) were done immediately and 3 months postoperatively, then collected data were statistically analyzed.Results: After 3 months, Bone height (mm) showed significant difference between the tested groups where Group A (CaSO4.1/2H2O) produced the highest mean Bone height followed by Group B (PRF) and Group C (Control) respectively. Bone width (mm) showed insignificant differences between the tested groups. Bone density showed insignificant differences between the tested groups.Conclusion: (1) CASO4 showed superior outcome as a graft material in extraction sockets. (2)PRF may represent a simple and effective means of accelerating new bone growth without use of barrier membranes or exogenous thrombin associated with other PRP systems. (3) Socket preservation may aid in reducing the bone dimensional changes following tooth extraction. However, they do not prevent bone resorption.