Objectives: The current study was conducted to evaluate the safety and efficiency of ACCUFUSER® ELASTOMERIC INFUSION DEVICE in patient-controlled sedation (PCS) during surgical removal of impacted lower third molars.Materials and methods: The twenty patients were equally divided into two groups chosen randomly. In both groups, 0.03 mg/kg Midazolam and 0.5 mg/kg Propofol were administered as a bolus dose.•Group 1 was then given 0.3 mg/kg/hr Ketamine and 1.2 mg/kg/hr Propofol as a maintenance dose delivered through the PCS pump.•Group 2 was then given 0.3 mic/kg/hr Fentanyl and 1.2 mg/kg/hr Propofol as a maintenance dose delivered through the PCS pump.For all the patients, the surgical procedure was performed under local anaesthesia and I.V. sedation. Before going to the operating theatre all patients were instructed about the PCS pump (ACCUFUSER® ELASTOMERIC INFUSION DEVICE) and familiarized with it.After the 5th minute of sedation, 4 mL of local aesthetic was administered. After ensuring the profoundness of the local anaesthetic, the surgical procedure began as previously explained.Patients in both groups were evaluated for hemodynamic stability, sedation level, patients’ satisfaction, surgeon’s satisfaction, level of amnesia, psychomotor recovery and adverse effects.Results: The results of this study showed no statistical difference between the two groups. The use of different drug combinations in both groups showed hemodynamic stability, moderate levels of sedation, patients’ and surgeon’s satisfaction, some degree of postoperative amnesia and rapid psychomotor recovery. None of the patients in both groups suffered from any adverse reactions such as, nausea, vomiting, hallucinations, involuntary movements, or over-sedation.Conclusion: PCS can be considered as an efficient and safe option in minor oral surgeries providing the majority of patients with high satisfaction and relaxation, also providing the surgeons with good operating conditions and the cooperation of the majority of the patients. Fentanyl-Propofol and Ketamine-Propofol combinations were both safe with respect to hemodynamic changes and sedation levels with stable level of moderate sedation and absence of over-sedation or under-sedation states in any patient. These drug combinations also showed rapid recovery of psychomotor functions in all patients. Conscious sedation allows the patient to experience a less stressful surgery with an adequate level of postoperative amnesia.