A variety of injectable corticosteroid, hyaluronic acid and NSAIDS formulations are used to reduce the persistent pain associated with TMJ destruction. Localized drug delivery via intra-articular injections minimizes ectopic effects while alleviating joint pain and other symptoms.Current methods of intra-articular drug delivery are complicated by rapid degradation and clearance of injected pharmacologic agents, so that frequent injections and high concentrations are necessary. Microcarrier-based drug delivery systems, including hydrogels, polymeric microparticles, and liposomes can be used to sustained release of the injected drugs and thereby increase duration and potency of the drug. The liposomes also aid in drug targeting to the microphages and other inflammatory cells, in addition to the above, when the PC headgroups of the injected liposomes in the LD phase they were highly hydrated and therefore are expected to facilitate “hydrophilic” lubrication, thus improve joint movements.In our study, we tried to state the benefit of liposomal microcarrier by comparing the effect of liposomal corticosteroid (Lipotalon) intra-articular injection with that obtained by corticosteroid injection alone in treatment of internal derangement. Sixteen patients were selected all complaining from ADDWR. After history taking and careful clinical examination, a bite raising splint was constructed for all cases to ensure balanced occlusion and to create room in the posterior part of the joint for the anteriorly displaced disc by positioning the condyle more inferiorly.The 16 patients were divided into two group first group treated with Lipotalon (test group) and the second group treated with Diprofos (control group). The preoperative records (VAS, MIO, PM, LM, opening click and reciprocal click) was recorded and compared with that obtained at the follow up visits, the patients were followed up at 3 days, 10 days, 1 month and 3 months. The mean VAS for TMJ pain in both groups showed gradual decrease at 3 days and 10 days postoperative with further decrease by the end of the first month . At the third month follow up visits there was still further decrease of the mean VAS for the test group (Lipotalon group) while there is significant relapse of the cases in the second control group (Diprofos group).Concerning range of mouth movements ( aMIO-mPM-mLRM-mLLM) ,opening and reciprocal clicks in the current study, there was improvement in the range of mouth movements, opening and reciprocal clicks in both groups with slight more improvement in the Lipotalon group but There was no statistically significant difference between both groups throughout the follow up period except after 3 months where the values of MLRM of group 1 was statistically significantly higher than values of group 2.We concluded from these results that the liposomes withDPPC (1,2-dipalmitoyl-sn-glycero-3-phosphocholine) membrane phospholipids of Lipotalon did not have significant lubrication function in comparison to glucocorticoids injection alone.