Aim of the study: This current in vitro study was carried out to evaluate the effect of crosslinking and electrobonding on the microshear bond strength of resin composite to dentin. Materials and Methods: Twenty intact human premolar teeth that were extracted for orthodontic purposes were used. After adequate surface debridement, the teeth were divided into two equal groups (10 each) according to the application of the crosslinking agent (C) (Grape seed extract). In group C0, the crosslinking agent was not applied, which is the control group, while in group C1, the crosslinking agent was applied. Each group was further subdivided into 2 subgroups (5 teeth each) according to electric current application during bonding (E); where in subgroup E0, no electric current was applied, while in subgroup E1, an electric current was applied. Then the restorative material was applied according to the manufacturer instructions. Microshear bond strength was measured using a universal testing machine. Results: The results showed that group C0 was significantly higher than group C1. However, no significant difference was recorded between group E0 and E1. While the results of all tested groups showed that the control group was significantly higher than other groups, with no significant difference between the control group and group with electrobonding application only. Conclusions: 1. The application of grape seed extract to dentin, separately or combined with electrobonding, was detrimental to the acquired bond to resin composite. 2. Electrobonding alone had a negligible effect on the bond of resin composite to dentin.