Objective: The aim of this study was to evaluate the remineralizing potential oftwo salivary substitutes on demineralized subsurface caries like lesions.Materials and Methods: 150 Dentin specimens were immersed in demineralizingsolution at PH 5.0 for 5 days at room temperature. 30 specimens were acted as acontrol group and were tested before and after demineralization. The remainingspecimens were stored in two salivary substitutes (Glandosane; cell pharm or Salivanatura; SN, Medac) for testing period; one week, one month and three months.Differences in mineral parameters before and after storage were evaluated usingusing Enviromental Scanning Electronc Microscope (ESEM) and Energy DispersiveAnalytical X- Rays (EDAX).Results: After storage periods (one week, one month and three months)Glandosane induced a significant demineralization of dentin specimens. The mineralsloss of specimens stored in Glandosane were significantly higher compared to Salivanatura (P˂ 0.001). While Saliva natura enabled considerable highly significant[2]remineralization after storage for one week but this was decreased after one and threemonths.Conclusion: Saliva natura has remineralizing properties while Glandosane has ademineralizing salivary substitute.