Objectivs: The aim of this study is clinical and radiographic evaluation of calcium sulfate and Platelet-rich plasma (CS-PRP), as an osteoinductive material used for ridge preservation after extraction of lower anterior teet h.Patients and Methods: A total of twelve patients, who were treatment planned for extraction of 4-6 mandibular anterior teeth. Atraumatic extractions were done for Fifty two teeth. Twenty six sockets were filled with (CS-PRP), while the other twenty six sockets were not grafted to serve as control. Results: The mean and standard deviation values of bone density after 9 months were 51.2 ± 11.6 in control group and 66.7 ± 25.6 in CS-PRP group. CS-PRP group showed statistically significantly higher mean bone density than control group. The mean and standard deviation values of bone height measurements after 9 months were 7.5 ± 1.9 mm in control group and 6 ± 1.9 mm in CS-PRP group. Control group showed statistically significantly higher mean bone height measurement (bone loss) than CS-PRP group. Coclusion: From the results of the current study, we concluded that, CS-PRP is ridge preservation graft biomaterial by it’s ability to decrease loss in both ridge height and density after tooth extraction.