Purpose: To evaluate the frequency of metastasis to Sublevel IIB lymph nodes inpatients with squamous cell carcinoma of the oral cavity - related to the site of primarytumor - in patients undergoing Therapeutic neck dissection in a large cohort of patients.Materials and methods: This work was conducted between September 2013 and June2016. Cases were selected from out-patient clinic in the National Cancer Institute , CairoUniversity. Thirty patients with 30 neck dissection were included in this study. All caseswere subjected to surgical resection of the primary site with safety margin according to thestandard protocol for each site, functional neck dissection for neck lymph nodes anddissection for sublevel IIB lymph nodes separately.Results: 30 patients were included in this study with 30 neck dissections, Examination ofthe level IIB proved: positive in 1 cases; the case was SCC of the tongue 9%, All the othercases of oral cavity were negative.Conclusions: Based on our observation and interpretation of the data result on our studywe can conclude that: Metastatic spread of oral cavity SCC to level IIB in cases ofclinically positive neck (cN+) is rare. Metastasis at sublevel IIB is observed withoutmetastasis at levels IIa, III or IV in one case of tongue SCC.