The effect of platelet rich plasma in combination with bio-active glass on the peri-implant bone healing. Aim: To evaluate the effect of platelet rich plasma in combination with bio-active glass on the peri-implant bone healing. Methodology: Twelve two-Stage implants were immediately inserted into fresh extraction sockets of upper single rooted teeth of twelve patients. The age range was between 25 and 45 years. The twelve implants were randomly divided into two groups. Group I; in which six implants were inserted into the extraction sockets and the gap around the implant was filled with bio-active glass only. Group II; in which six implants were inserted into the extraction sockets and the gap was filled with bio-active glass mixed with autogenous platelet-rich plasma (PRP) prepared from the patient's own blood. Direct digital radiography (Digora) was used to measure the bone density in the implant-bone interface immediately, one month, three months and six months postoperatively. Results: There was no statistically significant difference between mean bone density measurements at the mesial and distal sides of each group. Immediately post-operative, after one month and after three months; there was no statistically significant difference between mean bone density measurements in the two groups. After six months; group II showed statistically significantly higher mean bone density measurement than group I. After one and three months, there was no statistically significant difference between percent changes in bone density in the two groups. After six months, group II showed statistically significantly higher mean percent increase in bone density than group I. Conclusion: Addition of platelet-rich plasma to the bio-active glass ingap around immediate dental implants, improves the radiographic bone density in bone-implant interface during healing period in compare to using bio-active glass only.