The purpose of this study is to clinically and radiographically evaluate the osteoconductive effect of platelet rich fibrin (PRF) combined with bioactive glass as graft material on repairing of the surgically created bony defects following cysts enucleation. The study was conducted on twelve patients suffering from cystic lesions. The cystic lesions were surgically enucleated according to the standard techniques and the resulting surgical defects were grafted using bioactive glass. The patients were divided randomly into two groups of six patients each. The first group was grafted with bioactive glass along with platelet rich fibrin (PRF) while the second group which is the control group was grafted using bioactive glass only. Data were collected and statistically analyzed by applying T –test. The bioactive glass exhibits bioactive behavior, without escape or migration of the granules from the cystic defects. Addition of PRF to bioactive glass allograft accelerates regenerative capacity of bone Comparing the two groups, Independent sample t-test showed no statistical significant difference in the bone density between the two groups throughout the study period.