Aim of the study: to evaluate the use of temporalis muscle flap in conjunction with free autogenous iliac bone graft in maxillary reconstruction. Patients and methods:The study included six patients,five patients had maxillary tumors. The sixth case was suffering from mucormycosis infection. Treatment plane included three phases; resection, reconstruction (iliac and temporal donor sites) and follow-up phases clinically and by digital subtraction angiography (DSA). Results: At one week postoperatively, bulky temporalis muscle flap partially encroached on the palate without affection on airway patency. One month postoperatively, muscle flap showed observable shrinkage with epithelization of the surface. Three months postoperative DSA follow-up showed increase in the average caliber with smooth tapering course, regular outline of the vessels with the absence of stricture or aneurysm formation indicated increasing in the blood supply to the muscle flap explaining its viability. Conclusion: Temporalis muscle flap was a versatile flap for maxillary defects reconstruction. Digital subtraction angiography is a gold standard for evaluation of the vasculature of the translocated flap.